Clinical and Experimental Pediatrics

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Review Article

Skin and oral intervention for food allergy prevention based on the dual allergen exposure hypothesis

Kiwako Yamamoto-Hanada, Yukihiro Ohya

Early-onset atopic dermatitis increases the risk of food allergies, suggesting that transcutaneous sensitization may occur through inflamed skin. Regarding food allergy causation, the dual allergen exposure hypothesis proposes that oral-route allergen exposure leads to immune tolerance, whereas allergen exposure via the inflamed skin causes food allergy. This hypothesis implies that it is important to induce oral immune tolerance and prevent...

DOI: https://doi.org/10.3345/cep.2023.00045 [Accepted]

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